The Tenth International Conference on Digital Presentation and Preservation of Cultural and Scientific Heritage—DiPP2020 was held from 24 to 26 September 2020 in the Burgas. DiPP2020 is organized under the patronage of UNESCO and Burgas Municipality and is partly funded by the National Scientific Fund of Bulgaria. 25 papers and several national and international projects on digital preservation and presentation of cultural and scientific heritage were presented. The forum was attended by more than 100 people. In response to travel and meeting difficulties posed by the COVID-19, DiPP2020 was provided in a virtual format and the registered delegates were able to participate virtually as well as in-person. The papers were published in a volume of proceedings of the conference as well as online at: http://dipp.math.bas.bg. DiPP2020 conference web site is: http://dipp2020.math.bas.bg. Special attention was given to the Workshop on Virtual Museums and Their Educational Applications, organized in the frame of the Cultural Heritage, National Memory and Social Development National Research Program.