The Eleventh International Conference on Digital Presentation and Preservation of Cultural and Scientific Heritage—DiPP2021 was held from 23 to 25 September 2021 in the Burgas. DiPP2021 is organized under the patronage of UNESCO and Burgas Municipality and is partly funded by the National Scientific Fund of Bulgaria. 30 papers and several national and international projects on digital preservation and presentation of cultural and scientific heritage were presented. The forum was attended by more than 60 people. The papers were published in a volume of proceedings of the conference as well as online at: http://dipp.math.bas.bg. DiPP20210 conference web site is: http://dipp2021.math.bas.bg. Special attention was given to the Workshop on New Educational Applications of Digital Cultural Content, organized in the frame of the Cultural Heritage, National Memory and Social Development National Research Program, and the Twelfth National Information Day: Open Science, Open Data, Open Access, Bulgarian Open Science Cloud organized in the frame of the National Scientific Program "Information and Communication Technologies for a Single Digital Market in Science, Education and Security".