The Twelfth International Conference on Digital Presentation and Preservation of Cultural and Scientific Heritage—DiPP2022 was held from 23 to 25 September 2022 in the Burgas. DiPP2022 is organized under the patronage of UNESCO and Burgas Municipality. 29 papers and several national and international projects on digital preservation and presentation of cultural and scientific heritage were presented. The forum was attended by more than 70 people (on-site and virtually). The papers were published in a volume of proceedings of the conference as well as online at: http://dipp.math.bas.bg. DiPP2022 conference web site is: http://dipp2022.math.bas.bg. Special attention was given to the Workshop on Approaches, Models and Tools for Digitization of Specific Ethnographic Objects, organized in the frame of the international project Europe Ritual Cuisine – Digital Presentation and Preservation (EURICA), and the Information Day Research Infrastructure Services in the Humanities and Social Sciences, organized in the frame of the CLaDA-BG, the Bulgarian National Interdisciplinary Research e-Infrastructure for Resources and Technologies in Favor of the Bulgarian Language and Cultural Heritage, Part of the EU Infrastructures CLARIN and DARIAH. Traditionally, the Workshop and national information day Open Access to Scientific Publications, Data and Data Science, Bulgarian Open Science Cloud were organized.