The Sixth International Conference on Digital Presentation and Preservation of Cultural and Scientific Heritage—DiPP2016 was held from 26 to 28 September 2016 in the Regional Museum of History and the P.R. Slaveykov Regional Public Library in Veliko Tarnovo, Bulgaria. DiPP2016 is organized under the patronage of UNESCO and is partly funded by the National Scientific Fund of Bulgaria. The forum was attended by more than 70 people, 35 papers and several national and international projects on digital preservation and presentation of cultural and scientific heritage were presented. The papers were published in a volume of proceedings of the conference as well as online at the official web site of the conference: The web site also contains information on the objectives and subject areas of the conference, accompanying events, programme, programme committee, participants, etc.